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| Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | David Wooderson | 217 | 636 | 2037 | |
| 2. | Randall Reach | 196 | 605 | 2045 | |
| Timothy Service | 196 | 610 | 2034 | ||
| 4. | Randall Reach | 192 | 615 | 2041 | |
| Eldon Decamp | 192 | 636 | 2038 | ||
| 6. | Eldon Decamp | 191 | 699 | 2037 | |
| 7. | John Yossarian | 189 | 631 | 2044 | |
| Carlos Olivas | 189 | 593 | 2041 | ||
| George Serrano | 189 | 618 | 2032 | ||
| 10. | Stuart Johnson | 187 | 619 | 2034 | |
| 11. | Anthony Lamotta | 186 | 634 | 2043 | |
| 12. | Michael Corlett | 185 | 656 | 2044 | |
| John Yossarian | 185 | 617 | 2041 | ||
| 14. | Calvin McNeill | 184 | 612 | 2028 | |
| 15. | John Yossarian | 183 | 635 | 2040 | |
| Richard Pecora | 183 | 623 | 2032 | ||
| David Marden | 183 | 662 | 2031 | ||
| 18. | Lawrence Deck | 182 | 643 | 2047 | |
| James Lonefeather | 182 | 620 | 2037 | ||
| Ernesto Labarbera | 182 | 622 | 2032 | ||
| 21. | John Yossarian | 181 | 637 | 2047 | |
| James Lonefeather | 181 | 595 | 2036 | ||
| Stuart Johnson | 181 | 621 | 2029 | ||
| 24. | Randall Reach | 180 | 558 | 2048 | |
| Benito Panjo | 180 | 579 | 2040 | ||
| Dennis Arends | 180 | 663 | 2035 | ||
| John Feather * | 180 | 614 | 2032 | ||
| 28. | David Wooderson | 179 | 627 | 2038 | |
| John Feather * | 179 | 602 | 2035 | ||
| Stuart Johnson | 179 | 626 | 2033 | ||
| 31. | Ernesto Labarbera | 178 | 629 | 2035 | |
| Salvador Munro | 178 | 663 | 2034 | ||
| 33. | John Feather * | 177 | 593 | 2036 | |
| Ernesto Labarbera | 177 | 614 | 2034 | ||
| Gary Ricker | 177 | 653 | 2032 | ||
| 36. | John Feather * | 176 | 613 | 2039 | |
| Ernesto Labarbera | 176 | 609 | 2036 | ||
| 38. | Benito Panjo | 175 | 588 | 2034 | |
| Gonzalo Mejias | 175 | 598 | 2028 | ||
| 40. | Gunner Esiason | 174 | 629 | 2046 | |
| John Feather * | 174 | 607 | 2034 | ||
| Claudio Cervantes | 174 | 626 | 2027 | ||
| 43. | Randall Reach | 173 | 659 | 2047 | |
| Benito Panjo | 173 | 553 | 2042 | ||
| Dave Parker | 173 | 525 | 2038 | ||
| David Wooderson | 173 | 638 | 2034 | ||
| Lewis Zeman | 173 | 643 | 2032 | ||
| David Wooderson | 173 | 635 | 2032 | ||
| James Meurer | 173 | 619 | 2032 | ||
| Curtis Flood | 173 | 586 | 2031 | ||
| Ba-To Honzo | 173 | 651 | 2028 | ||
| 52. | David Evans | 172 | 675 | 2046 | |
| Carlos Olivas | 172 | 590 | 2040 | ||
| James Lonefeather | 172 | 626 | 2038 | ||
| John Feather * | 172 | 585 | 2038 | ||
| Carlos Olivas | 172 | 563 | 2037 | ||
| Jose Valles | 172 | 573 | 2030 | ||
| 58. | Randall Reach | 171 | 629 | 2040 | |
| Fred McVeigh | 171 | 654 | 2031 | ||
| 60. | Anthony Lamotta | 170 | 623 | 2044 | |
| John Yossarian | 170 | 623 | 2043 | ||
| Randall Reach | 170 | 632 | 2042 | ||
| Richard Pecora | 170 | 618 | 2035 | ||
| Calvin McNeill | 170 | 655 | 2026 | ||
| 65. | John Yossarian | 169 | 639 | 2045 | |
| David Wooderson | 169 | 641 | 2036 | ||
| Jorge Posada | 169 | 609 | 2031 | ||
| Paul Nightingale | 169 | 632 | 2027 | ||
| Francisco Cavallo | 169 | 637 | 2026 | ||
| 70. | Donald Fraley | 168 | 593 | 2036 | |
| Kurt Boehme | 168 | 620 | 2035 | ||
| Ricky Byrnes | 168 | 648 | 2028 | ||
| 73. | Michael Corlett | 167 | 643 | 2045 | |
| Carlos Olivas | 167 | 508 | 2043 | ||
| Anthony Lamotta | 167 | 649 | 2040 | ||
| Guy Jose Jr | 167 | 600 | 2038 | ||
| David Wooderson | 167 | 577 | 2035 | ||
| Donny Tram | 167 | 685 | 2034 | ||
| Jeff Ross | 167 | 559 | 2033 | ||
| Gary Ricker | 167 | 647 | 2031 | ||
| Henry Greenberg | 167 | 672 | 2029 | ||
| Andy Reagan | 167 | 632 | 2028 | ||
| 83. | Randall Reach | 166 | 580 | 2046 | |
| Randall Reach | 166 | 538 | 2044 | ||
| John Yossarian | 166 | 623 | 2042 | ||
| Alex Ovechkin | 166 | 609 | 2035 | ||
| Salvador Munro | 166 | 645 | 2032 | ||
| Eugene Jones | 166 | 590 | 2031 | ||
| Ramon Farina | 166 | 582 | 2030 | ||
| Stuart Johnson | 166 | 598 | 2028 | ||
| Celestino Vilas | 166 | 614 | 2027 | ||
| 92. | Carlos Olivas | 165 | 558 | 2038 | |
| Dennis Arends | 165 | 630 | 2034 | ||
| Stuart Johnson | 165 | 651 | 2031 | ||
| Vicente Francois | 165 | 653 | 2028 | ||
| Francisco Cavallo | 165 | 659 | 2025 | ||
| 97. | Michael Corlett | 164 | 661 | 2048 | |
| Ronaldo Caldera | 164 | 570 | 2047 | ||
| John Yossarian | 164 | 658 | 2046 | ||
| Jeffrey Gillmore | 164 | 630 | 2040 |
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